Intravenous Vitamin Infusion Therapy (IV Therapy)

Which Vitamins are important for Fertility?

 

IV Nutrient therapy in Ottawa, ON Canada is used for the treatment of many different conditions. It can also be utilized to help support the treatment of female and male infertility. Intravenous vitamin infusions are an innovative method to deliver key minerals and nutrients vital in improving male fertility and sperm health. It can also be used to help protect eggs from damage by delivering high concentration antioxidants and vitamins to support egg quality. 

The most vital ingredient that can be delivered through IV therapy is Glutathione. Glutathione is the main antioxidant compound in the body and has a vital role in protecting sperm cells from damage. It has been shown to help support healthy sperm motility and normal sperm morphology. Glutathione and Vitamin C are two of the main antioxidant compounds which concentrate heavily in the seminal fluid to protect sperm cells from the reactive oxygen species (ROS) they are exposed to. Vitamin C and Glutathione both can be provided in concentrations much higher through an intravenous nutrient infusion than possible with just an oral pill. 

Glutathione is also very important for female infertility and egg quality. Higher glutathione concentrations have been associated with an increased number of embryos which make it to day 5 Blastocyst stage (high quality embryos) during IVF, and lower glutathione levels in the ovary have been associated with a reduced number of follicles making it to the day 5 blastocyst stage. As an antioxidant it supports quality and reduces oxidative stress from harming egg quality.

Additional ingredients that can be added to support fertility for both Men and Women are Carnitine, Arginine, Selenium and Vitamin C. Carnitine helps to improve sperm motility, increase concentration and it also improves egg quality. Arginine helps to improve blood flow to the reproductive organs. The arginine helps to support a healthy uterine lining and can improve thickness of the lining for Women struggling with a thin uterine lining

Vitamin C has a crucial role as an antioxidant to support fertility, it also reduces oxidative stress and damage to the eggs and sperm cells. It may help to support optimal progesterone levels, help reduce stress, improve energy, and support the immune system.

Selenium has a crucial role in supporting thyroid function and may help to reduce complications during pregnancy. In particular, it may help to reduce the risk of postpartum hypothyroidism.

For more information see IV Therapy Ottawa

What are the benefits of Intravenous Vitamin Infusion Therapy (IVIT)?

 

IV therapies allow for the delivery of vital nutrients and vitamins directly to the bloodstream. This is the key difference between IV therapy and oral supplements which gives an advantage in providing an improved treatment outcome for various conditions. Mainly because when we take oral supplements (or the nutrients present in our diet) have a specific threshold beyond which they can no longer be absorbed in the digestive tract (gut lumen). Secondly, all nutrients absorbed from the digestive tract pass through the organ in charge of detoxification for the whole body, the liver. The liver will, in many cases, breakdown a significant portion of the therapeutic agents. This is called the ‘first-pass metabolism’ and leads to a decreased dose that is actually delivered to the blood for the remainder of the organs to utilize. Intravenous delivery of these nutrients overcomes the first-pass metabolism and delivers a significantly higher concentration of the therapeutic agents to the bloodstream which can then be utilized by the organs of the body. An example of this is IV Vitamin C, which can increase the blood concentration of ascorbic acid by almost 80x higher than what oral supplementation is able to achieve. 

What is the process of receiving an IV Therapy?

 

  1. You are instructed to arrive for your intravenous infusion well-hydrated and having had a decent sized meal within the last couple of hours before your infusion. 

  2. You will get comfortable in a leather reclining chair in our IV Suite that is filled with natural light and a relaxing environment with gentle music. 

  3. After taking your vitals (blood pressure, heart rate, temperature, and respiratory rate), the clinician will inspect the veins and select the most comfortable vein for the treatment. Once selected the site where the needle will be inserted is disinfected.

  4. The needle is inserted in to the vein, and once in, the catheter (flexible plastic tube) is slipped off of the needle and in to the vein, and the needle is retracted and disposed of.

  5. The IV bag tubing (sterile plastic tube connected to the IV bag) is attached to the catheter and finally…

  6. The IV therapy commences and the catheter is taped down to the skin with easy-to-remove tape to ensure the catheter remains stable while the distal portion (the tube) remains inserted in the vein.

Intravenous vitamin infusions can also be used in the treatment of various other conditions, some of them occurring with the fertility journey to a healthy pregnancy. Some of the formulas which can be done concurrently with the above mentioned treatments include, but are not limited to:

 

  • Intravenous Myers’ Cocktail: this is a specific blend of nutrients (high dose B-Vitamins, ascorbic acid, magnesium, zinc, and more) which was studied by Dr. Myers MD. It was used to support the treatment of chronic fatigue syndrome and fibromyalgia. In fact, the use of the Myers’ cocktail in a 2009 double-blind, placebo controlled, and randomized trial found within-group significant changes with an improvement in pain, fatigue, and decreased feelings of depression, although compared to the control group the improvement didn’t reach statistical significance. Another research trial found that patients who were resistant to conventional treatment (meaning they no longer were getting any benefit from prescription medications) saw a significant increase in energy, improvement in quality of life, reduction in pain, and a reduction in fatigue. 

  • Intravenous Glutathione has been shown to support other conditions, such as, certain liver conditions and can also help reduce wrinkles in the skin, improve skin elasticity, and decrease UV spots present on the skin.

  • Intravenous magnesium: can be beneficial in the treatment of myalgia (muscular pain), support treatment for certain cardiac arrhythmias, and reduce muscle cramping

  • Pregnancy Glow Formula: contains ingredients to reduce morning sickness and nausea, reduce muscle cramps common in pregnancy (leg cramps) and minerals to support thyroid health during pregnancy and prevent thyroid complications after giving birth. The formulas contains ingredients which have been suggested to reduce the risk of certain complications during pregnancy, such as, hypertension and diabetes. This also beneficial in hydration for patients unable to keep food and drink down with severe morning sickness. In some cases and additional bag of saline fluids is added at the end of the treatment to continue hydrating and help with relaxation.  

References:

  1. Irvine, D. (1996). Glutathione as a treatment for male infertility. Reviews of Reproduction, 1(1), 6–12.

  2. Mills, J., & Yao, D. (2016). Male infertility: lifestyle factors and holistic, complementary, and alternative therapies. Asian Journal of Andrology, 18(3), 410.

  3. Mora-Esteves, C., & Shin, D. (2013). Nutrient Supplementation: Improving Male Fertility Fourfold. Seminars in Reproductive Medicine, 31(04), 293–300.

  4. Ozawa, M., Nagai, T., Fahrudin, M., Karja, N. W. K., Kaneko, H., Noguchi, J., Kikuchi, K. (2006). Addition of glutathione or thioredoxin to culture medium reduces intracellular redox status of porcine IVM/IVF embryos, resulting in improved development to the blastocyst stage. Molecular Reproduction and Development, 73(8), 998– 1007.

  5. Hidaka, T., Fukumoto, Y., Yamamoto, S., Ogata, Y., & Horiuchi, T. (2018). Variations in bovine embryo production between individual donors for OPU-IVF are closely related to glutathione concentrations in oocytes during in vitro maturation. Theriogenology, 113, 176–182.

  6. Nishihara, T., Matsumoto, K., Hosoi, Y., & Morimoto, Y. (2018). Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in vitro fertilization outcome. Reproductive Medicine and Biology, 17(4), 481–486.

  7. Majzoub, A., & Agarwal, A. (2018). Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate. Arab Journal of Urology, 16(1), 113–124.

  8. Smits, R. M., Mackenzie-Proctor, R., Yazdani, A., Stankiewicz, M. T., Jordan, V., & Showell, M. G. (2019). Antioxidants for male subfertility. Cochrane Database of Systematic Reviews.

  9. Henmi H, Endo T, Kitajima Y, et al. Effects of ascorbic acid supplementation on serum progesterone levels in patients with luteal phase defect. Fertil Steril 2003;80:459-61.

  10. Igarashi M. Augmentative effect of ascorbic acid upon induction of human ovulation in clomiphene-ineffective anovulatory women. Int J Fertil 1977;22:168-73. 

  11. Showell, M. G., Mackenzie-Proctor, R., Jordan, V., & Hart, R. J. (2017). Antioxidants for female subfertility. Cochrane Database of Systematic Reviews.

  12. Agarwal, A., Sengupta, P., & Durairajanayagam, D. (2018). Role of L-carnitine in female infertility. Reproductive Biology and Endocrinology, 16(1).

  13. Battaglia, C., Salvatori, M., Maxia, N., Petraglia, F., Facchinetti, F., and Volpe, A. Adjuvant L-arginine treatment for in-vitro fertilization in poor responder patients. Hum.Reprod. 1999;14(7):1690-1697.

  14. Appleton, J. (2002). Arginine: Clinical Potential of a Semi-Essential Amino Acid. Alternative Medicine Review, 7(6), 512–522.

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