top of page
  • Writer's pictureDr. H. Singh, ND

3 Vitamins Associated with Doubled IVF Success Rate

fertility supplement for ivf

Infertility treatments can be extremely challenging for many Patients and therefore discussing valuable treatments to improve supporting success rates can be incredibly beneficial. Recent developments in fertility research have observed potential benefits of using a higher quality B-Complex supplement during IVF treatments. A 'first of its kind' study has found positive associations between specific B vitamins and significantly improved IVF outcomes.

Comprehensive B-Vitamin Formula vs Folic Acid

In a recently published study, researchers discovered that incorporating Vitamin B6, Vitamin B12, and 5-methyltetrahydrofolate (bioactive form of folic acid) into the daily supplement regimen was linked to remarkable improvements in IVF success rates. Couples who embraced this comprehensive B-Complex approach experienced double the chances of a successful clinical pregnancy test and an impressive 83% higher likelihood of a live birth compared to those using standard folic acid alone.

Hyperhomocysteinemia Negatively Affects Follicle Health

The mechanism behind these positive findings potentially lies in the role of B vitamins being able to reduce homocysteine levels. Hyperhomocysteinemia, characterized by elevated levels of homocysteine in the blood, can contribute to cell damage and increased oxidative stress. Elevated homocysteine levels in the reproductive organs can impair egg maturation and hinder embryo development. Supplementing with the combination of Vitamin B6, Vitamin B12, and 5-methyltetrahydrofolate may help to effectively lower homocysteine levels, creating a healthier reproductive environment for successful IVF outcomes.

Hyperhomocysteinemia and Implantation:

Hyperhomocysteinemia can exert negative effects on trophoblasts, the cells that play a crucial role in the implantation process during pregnancy. Elevated homocysteine levels may adversely impact trophoblast function, potentially hindering the implantation of the embryo. Therefore, addressing hyperhomocysteinemia through B-Vitamins supplementation may not only enhance egg/embryo health but also positively influence the crucial phase of implantation.

Egg Maturation and Fertilization:

Supplementation with the combination of B-Vitamins (B6, B12 and 5-MTHF) was also associated with an improved egg maturation and fertilization rate when compared to those supplementing with folic acid alone.

The 5-Methyltetrahydrofolate Advantage:

One standout component of the B-Complex supplement is 5-methyltetrahydrofolate, a bioactive form of folate. Unlike folic acid, which requires further conversion into 5-mthf to be utilized by the body, 5-methyltetrahydrofolate is already bioactive. This distinction is crucial for individuals who may have heterozygous or homozygous 5-MTHFR gene mutations (C677T or A1298C), impairing their ability to convert folic acid to its bioactive form and potentially leading to elevated homocysteine levels.


While these findings are undoubtedly promising, it's essential to approach them with a level of caution. The current insights are derived from an observational study, establishing correlation but not confirming causation. Further research is needed to solidify whether a comprehensive B-Complex with the bioactive form of folate is indeed superior to folic acid alone in enhancing IVF outcomes. As always, speak to your Naturopathic Doctor or Fertility Care Team and only change nutritional supplements under medical supervision.

This article is being shared as educational content and is in no way a replacement for medical advice or medical care, it is advised that anyone concerned about their Health should speak with their Naturopathic Doctor. Please discuss with your healthcare provider and only make changes to your medications regimen if recommended by your doctor and under their guidance and supervision.

141 views0 comments


bottom of page