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  • Writer's pictureDr. H. Singh, ND

Could Vitamin B3 Increase Egg Quality and Improve Fertility? Exploring NAD+ for Infertility

Nicotinic Acid, commonly known as Vitamin B3, plays a crucial role in various metabolic processes within the body. One of its key contributions lies in the production of Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme that impacts cellular functions and can potentially mitigate the negative effects of oxidative stress on cellular aging. For patients grappling with infertility, understanding the significance of NAD+ and exploring ways to enhance its activity becomes paramount.

The Role of NAD+ in Reproductive Health:

NAD+ is indispensable for cellular energy production, DNA repair, and maintenance of genomic stability. In the context of reproductive health, optimal NAD+ levels are associated with improved cellular function, which may positively impact fertility. However, the scientific exploration of NAD+ in the realm of infertility is still in its early stages, with limited studies focusing mainly on animals.

Increasing NAD+ Activity:

There are three primary ways to boost NAD+ activity in the body:

  1. Supplementation with Precursors:

  • Nicotinic Acid and Nicotinamide (Vitamin B3): These are essential precursors for NAD+ synthesis. Including foods rich in Vitamin B3 in the diet or considering B3 supplementation can contribute to NAD+ production.

  • Tryptophan: Amino acid tryptophan, found in various foods, serves as a precursor for an important NAD+ intermediate. The liver converts tryptophan into NAD+, further supporting cellular functions.

  1. Dietary Sources of Nicotinamide Riboside:

  • Nicotinamide riboside is another precursor for NAD+ that can be obtained from certain foods. Incorporating these sources into the diet can contribute to maintaining healthy NAD+ levels.

  1. Lifestyle Changes:

  • Exercise: Engaging in low to moderate-intensity physical activity has been associated with numerous health benefits, including supporting NAD+ activity. Regular exercise is a cost-effective and accessible means to promote overall well-being and potentially enhance reproductive health.

Considerations for NAD+ Boosting Supplements:

While the potential benefits of NAD+ supplementation are intriguing, it's crucial to note that research in the context of infertility is still in its infancy, largely limited to animal studies. Therefore, investing in expensive supplements solely for this purpose may not be advisable at this time.

Cost-Effective Ways to Support NAD+ Activity:

Considering the central role of NAD+ in overall health, adopting lifestyle changes and improving dietary habits are practical and cost-effective approaches. Many precursors for NAD+ production, such as Vitamin B3, are readily available in our diets. Moreover, Vitamin B3 is a common component of prenatal supplements, emphasizing its importance for reproductive health.


While the scientific community continues to explore the intricate relationship between NAD+ and infertility, patients can take proactive steps to support NAD+ activity through accessible and cost-effective means. By incorporating Vitamin B3-rich foods, considering appropriate supplements, and embracing a healthy lifestyle, individuals can contribute to their overall well-being and potentially enhance reproductive health. As research progresses, a more nuanced understanding of the role of NAD+ in infertility may emerge, offering new possibilities for those navigating challenges in reproductive health.

This article is being shared as educational content and is in no way a replacement for medical advice or medical care, it is advised that anyone concerned about their Health should speak with their Naturopathic Doctor. Please discuss with your healthcare provider and only make changes to your medications regimen if recommended by your doctor and under their guidance and supervision.

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