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  • Writer's pictureDr. H. Singh, ND

One Vitamin that may Supercharge Fertility and PCOS Treatments

PCOS and infertility natural vitamin treatment

Polycystic Ovarian Syndrome (PCOS) is estimated to have a prevalence above 20% among biological females on the higher end of estimates. Approximately 46% of PCOS patients are estimated to experience infertility. For couples trying to manage the challenges of infertility and PCOS, emerging research sheds light on the significant role of thiamine, also known as Vitamin B1, in enhancing overall health and fertility, particularly for those dealing with PCOS.

Understanding the Link between Thiamine and Fertility

Thiamine, a crucial member of the B Vitamin family, plays a pivotal role in regulating fertility. Recent studies have shown that thiamine deficiency can lead to a reversible inhibition of oocyte maturation, resulting in an increased number of abnormal oocytes. Notably, women with PCOS have been observed to have lower serum Vitamin B1 levels compared to the general population, making thiamine supplementation a potential game-changer for those struggling with fertility issues related to PCOS.

Beyond Fertility: Thiamine's Impact on Psychological Wellbeing

The benefits of thiamine extend beyond fertility, research has found a crucial role for this vitamin in affecting psychological wellbeing. The nervous system relies on thiamine for optimal functioning, influencing conditions such as anxiety, depression, stress levels, and overall mood. A recent study utilizing the GHQ-28 questionnaire, a validated screening tool for psychological wellbeing, found that women with PCOS experienced significant improvements in overall health after supplementing with thiamine.

Fertility Boost and Improved Pregnancy Rates

In a groundbreaking study, women with PCOS who supplemented with thiamine demonstrated not only enhanced overall health but also notable improvements in fertility outcomes. The treatment group exhibited a higher number of retrieved follicles during fertility treatments and a significantly increased pregnancy rate compared to the control group that received a placebo. These findings suggest that thiamine supplementation could be a valuable addition to fertility treatment protocols for couples facing PCOS-related infertility.

Alleviating Depression, Boosting Energy, and Reducing Stress

Thiamine supplementation has been suggested to help alleviate symptoms of depression, improve energy levels, and reduce fatigue and stress. These benefits may be attributed to thiamine's role in increasing antioxidant capacity, supporting energy production, and improving energy utilization in neuronal cells. For couples on the fertility journey, addressing these factors may be crucial not only for conception but also for maintaining emotional well-being throughout the process.


Couples facing infertility challenges, especially those linked to PCOS, may benefit from adjunctive treatment with thiamine supplementation. As a critical player in regulating fertility, improving psychological wellbeing, and addressing symptoms associated with PCOS, thiamine opens new avenues for comprehensive fertility support. While further research is needed, the existing evidence underscores the importance of considering thiamine as part of a holistic approach to managing PCOS-related infertility. As always, consulting with healthcare professionals is essential before incorporating any supplements into fertility or PCOS treatment plans. With ongoing research, the future looks promising for couples seeking effective, natural solutions to enhance their fertility journey.

This article is being shared as educational content and is in no way a replacement for medical advice or medical care, it is advised that anyone concerned about their Health should speak with their Naturopathic Doctor. Please discuss with your healthcare provider and only make changes to your medications regimen if recommended by your doctor and under their guidance and supervision.

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