Novel Treatment that More than Tripled Pregnancy Rates
- Dr. H. Singh, ND
- Aug 11
- 2 min read
If you have been through one or more transfers without a positive outcome, you are not alone. One of the most overlooked factors in these situations is blood flow to the uterus. A new randomized and blinded clinical trial offers encouraging evidence that supporting the nitric oxide pathway to improve uterine blood flow may help patients with recurrent implantation failure during frozen embryo transfer.
New research examined the role of L-arginine (an amino acid) in improving blood flow to the uterus. The results of this treatment were astounding and demonstrated statistically significant improvement in pregnancy rates in Patients suffering from recurrent implantation failure (RIF).
Key findings you should know
Pregnancy outcomes improved in a statistically significant way.The group receiving the L-Arginine showed higher chemical pregnancy rates and higher clinical pregnancy rates compared with the control group. The treatment almost doubled the chemical pregnancy rate and more than tripled the clinical pregnancy rate compared to the control group
Blood flow to the uterus improved. Doppler measures of uterine artery resistance decreased for those receiving L-Arginine. Lower resistance suggests better arterial blood flow to the uterus.
The results were not explained by embryo quality. Embryo grading distribution was similar between groups, which supports that the difference in outcomes relates to the physiologic changes measured rather than embryo quality differences.
How Does L-Arginine Improve Pregnancy Rates?
The body makes nitric oxide from the amino acid L-arginine using enzymes called nitric oxide synthases. Nitric oxide then signals through cGMP inside vascular smooth muscle to relax the vessel wall. In the uterus, that relaxation is linked to better blood flow, which is important for implantation.
What this could mean for your care
If you have had one or more unsuccessful transfers, it is reasonable to ask whether uterine perfusion is part of the picture. In my practice we review your history, treatment protocols, medications and we design a plan that considers circulation to the uterine lining alongside other factors like the reproductive microbiome, inflammation, hormones, metabolic health, and much more.
A careful note on safety
This article is for education only. Please do not start any new supplement based on a blog post. Whether an L arginine based approach fits your situation should be discussed with your naturopathic doctor to determine safety, expected benefit, and any risk of interactions with your current medications or your treatment plan for transfer.
Book a consultation to explore your symptoms and history in more depth. Together, we can create a targeted, compassionate, and proactive strategy to support your reproductive health.
Disclaimer: This blog is for informational purposes only and should not be taken as medical advice. Always consult with your Naturopathic Doctor before starting any new supplement, especially during fertility treatments like IVF.
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