A common, and often underdiagnosed, cause of recurrent pregnancy loss is elevated DNA fragmentation of the sperm cells. Increased DNA fragmentation of sperm cells can result from various issues, one of the central ones being elevated oxidative stress.
A newly published study in the Journal of Fertility and Sterility treatment for the partner providing the sperm sample with alpha lipoid acid (ALA) for 80 days was found to help increase the health of sperm cells. There was a marked decrease in oxidative stress of the seminal fluid, improved sperm motility and reduced DNA damage.
Spontaneous pregnancy rates were almost double in the group of Patients treated with ALA versus placebo.
It is important to note that the treatment of recurrent miscarriages requires accurate and in-depth testing for both partners and further investigation in to the root cause of the issues. For example, in the absence of elevated oxidative stress and poor sperm health, treatment with antioxidants and ALA for the partner providing the sperm sample would not be indicated. However, treatment with these same interventions when there is poor DNA integrity in the sperm cells may make a substantial difference in outcomes. Therefore, an accurate understanding of the causative factors for the cause of miscarriage for each individual case is necessary before a treatment plan is formulated.
Therefore it is advisable to always seek professional care from healthcare providers focused in this area to help guide treatment rather than trying a random assortment of treatments that may be available.
Further investigation is required to confirm efficacy of ALA for the treatment of sperm-factor infertility with larger treatment and control groups.
Potential side effects of ALA supplementation include, but are not limited to, sleep disturbances/insomnia, digestive issues, skin rash, tiredness/fatigue and may lower blood sugar levels (caution is especially recommended for diabetics). For these reasons it is recommended to only use ALA under medical supervision.
This article is being shared as educational content and is in no way a replacement for medical advice or medical care, it is advised that anyone concerned about their Health should speak with their Naturopathic Doctor. Please discuss with your healthcare provider and only make changes to your medications regimen if recommended by your doctor and under their guidance and supervision.