Understanding the Genetics of Polycystic Ovarian Syndrome
Polycystic Ovarian Syndrome (PCOS) can be a challenging condition to treat. The development of PCOS seems to show some genetic correlation, but not a guaranteed cause and effect.
The development of PCOS may be linked to the genes that encode the Androgen Receptor (AR) in the body, which happens to be found on an X-Chromosome. During embryogenesis one of the two X chromosomes (all females have two X chromosomes) becomes inactivated, and if the female embryo has an X-chromosome that makes an abnormal AR that remains active, she may have an increased likelihood of developing PCOS later on in life. Similarly, if a female embryo has an X-chromosome that makes an abnormal AR but it becomes inactivated, then she may have a lower likelihood of developing PCOS later on in life.
The phenomenon described above is known as X-chromosome inactivation, and cannot be reversed once it occurs.
The development of the condition may also be influenced by Nutritional status of the mother during pregnancy. And certain symptoms, such as, precocious puberty, hair growth, and irregular menstrual cycles may start to show as early as menarche. Certain lifestyle conditions may also play a part in development or progression of PCOS. For some Women who have PCOS, but certainly not all Women, obesity can have an effect on progression of PCOS and possibly further worsening the symptoms.
This article is in no way a replacement for medical advice or medical care, it is advised that anyone concerned about their Reproductive Health should speak with their Naturopathic Doctor or Primary Care Provider.
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